＜本書の構成＞

本書は，1991年から2000年までの10年間に世界で新しく上市された新薬367品目について， その化学構造と製法の概要を収録し，製造工程の鍵となる中間体を特定することを第一の 目的として作成した。 　創製と開発に関わる情報および薬効についての記述も付け加え，合成法を中心とする参考 文献および主要特許については出来る限り原報を確認した。 　新薬367品目についてその製法を中心に調査し，見やすいように1品目1ページにまとめた。 記載項目は，名称・開発および上市に関する情報・薬効・化学構造・合成法・鍵中間体・ 参考文献・関連特許を掲載した。 　ついで，鍵中間体の化学構造式を分類，配列した一覧表を付しどの様な鍵中間体が使用さ れているかの分析を行った。本書に収録した合成・半合成医薬品335品目から539種の中間体 をピックアップ，脂肪族化合物・ベンゼン誘導体・複素環化合物，その他の4グループに分類 し，さらに鎖長，環の数，複素環原子の種類と数により細分類し，比較的簡単な構造から複雑 なものへと配列した。

＜目　　次＞

�T　新薬の動向(Trend in New Drugs) 　１．国別，会社別の新薬の創製と上市状況 　　1.1 新薬の創製 　　1.2 創製と上市 　　1.3 会社別動向 　　1.4 上市後の経過 　２．主要薬効分野別の新薬数と開発動向 　３．化学構造および製法からみた新薬 　　3.1 タイプ別の動向 　　3.2 合成品の立体化学 �U　鍵中間体の動向（Key Intermediates） �V　一般名リスト（List of Generic Names） �W　原体シート（Monographs） �X　薬効分類索引（Therapeutic Category Index） �Y　鍵中間体一覧表（Chart of Key Intermediates） Number Generic Name Year of First Introduction Introduced by 1 Abacavir sulfate (JAN, USAN) 1999 Glaxo Wellcome 2 Aceclofenac 1992 Prodes ; Sanofi-Winthrop 3 Actarit 1994 Nippon Shinyaku etc. 4 Alendronate sodium (USAN) 1993 Merck, Sigma Tau 5 Alglucerase 1991 Genzyme 6 Alitretinoin 1999 Ligand 7 Almotriptan maleate (USAN) 2000 Almirall Prodesfarma 8 Alosetron hydrochloride (USAN) 2000 Glaxo-Wellcome 9 Alpidem 1991 Synthelabo 10 Amifostine(USAN) (USP) 1995 Schering Plough 11 Amorolfine hydrochloride (JAN) 1991 Roche 12 Ampiroxicam 1994 Pfizer, Toyama 13 Amprenavir 1999 Glaxo Wellcome 14 Amtolmetin guacil 1993 Sigma Tau, Medosan 15 Anagrelide hydrochloride (USAN) 1997 Roberts 16 Anastrozole 1995 Zeneca 17 Angiotensin II 1994 Yamanouchi 18 Aniracetam 1993 Roche; Toyama etc 19 Aranidipine 1996 Taiho 20 Arglabin 1999 Nu Oncology Labs 21 Arteether 2000 Artecef BV 22 Atorvastatin calcium (USAN) 1997 Parke-Davis 23 Atosiban 2000 Ferring AB 24 Atovaquone 1992 Wellcome 25 Azasetron hydrochloride (JAN) 1994 Yoshitomi; Japan Tobacco 26 Balsalazide disodium (USAN) 1997 Astra 27 Barnidipine hydrochloride (JAN) 1992 Yamanouchi 28 Benidipine hydrochloride (JAN) 1991 Kyowa Hakko 29 Bepotastine besilate (JAN) 2000 Ube ; Tanabe 30 Beraprost sodium (JAN) 1992 Toray ; Yamanouchi 31 Betamethasone butyrate propionate 1994 Torii 32 Bexarotene 2000 Ligand Pharm. 33 Bicalutamide 1995 Zeneca 34 Bivalirudin 2000 The Medicines Company 35 Brimonidine tartrate (USAN) 1996 Allergan 36 Brinzolamide 1998 Alcon 37 Brodimoprim 1993 Fisons; Master Pharma 38 Bromfenac sodium hydrate (JAN) 1997 Wyeth-Ayerst 39 Budipine 1997 Promonta Lundbeck 40 Bulaquine 2000 CDRI 41 Butenafine hydrochloride (JAN) 1992 Kaken；Hisamitsu 42 Butibufen 1992 E Merck 43 Cabergoline 1993 Kabi Pharmacia 44 Calcipotriol (INN, JAN) (calcipotriene(USAN)) 1991 Leo Denmark 45 Candesartan cilexetil (JAN, USAN) 1997 Astra 46 Capecitabine 1998 Roche 47 Carperitide 1995 Zeria 48 Carvedilol 1991 Boehringer Mannheim 49 Cefcapene pivoxil hydrochloride (JAN) 1997 Shionogi 50 Cefdinir 1991 Fujisawa 51 Cefditoren pivoxil (JAN) 1994 Meiji Seika 52 Cefepime dihydrochloride (INN, JAN) 1993 Bristol-Myers Squibb 53 Cefetamet pivoxil hydrochlroride (JAN) 1992 Roche 54 Cefoselis sulfate (INN, JAN) 1998 Fujisawa 55 Cefotiam hexetil hydrochloride (JAN) 1991 Takeda 56 Cefozopran hydrochloride (JAN) 1995 Takeda 57 Cefpirome sulfate (JAN, USAN) 1992 Hoechst; Roussel Uclaf 58 Cefprozil(USP) 1992 Bristol-Myers Squibb 59 Ceftibuten (JAN) 1992 Shionogi 60 Celecoxib 1999 Searle/Pfizer 61 Centchroman 1991 Hindustan Latex 62 Centoxin 1991 Centocor 63 Cerivastatin sodium (JAN, USAN) 1997 Bayer 64 Cetrorelix acetate (USAN) 1999 Asta Medica 65 Cevimeline hydrochloride (USAN) 2000 Daiichi Pharm. 66 CHF-1301 1999 Chiesi Farmaceutici SpA 67 Cidofovir 1996 Gilead Sciences 68 Cilnidipine 1995 Fujirebio 69 Cinolazepam 1993 Gerot 70 Cisatracurium besilate (INN) 1995 Glaxo Wellcome 71 Cladribine 1993 Ortho Biotech 72 Clopidogrel bisulfate (USAN) 1998 Sanofi ; Bristol-Myers Squibb 73 Cloricromen hydrochloride 1991 Sinax (Fidia) 74 Colesevelam hydrochloride (USAN) 2000 Sankyo ; Pfizer 75 Colestimide (JAN) (Colestilan (INN)) 1999 Tokyo Tanabe 76 Colforsin daropate hydrochloride (JAN) 1999 Nippon Kayaku 77 Cytarabine ocfosfate (JAN) 1993 Yamasa ; Nippon Kayaku 78 Dalfopristin/quinupristin 1999 Aventis 79 Deferiprone 1995 Cipla 80 Delavirdine mesilate(JAN), mesylate(USAN) 1997 Pharmacia & Upjohn 81 Denileukin diftitox 1999 Ligand 82 Deprodone propionate (JAN) 1992 SS Pharmaceutical 83 Desflurane(USP) 1992 Anaquest 84 Dexfenfluramine hydrochloride (USAN) 1997 Servier 85 Dexibuprofen 1994 Gebro Broschek 86 Dexmedetomidine hydrochloride(USAN) 2000 Abbott 87 Dexrazoxane 1992 Euro Cetus 88 Dezocine 1991 Astra 89 Didanosine 1991 Bristol-Myers Squibb 90 Dirithromycin(USP) 1993 Lilly 91 Docarpamine 1994 Tanabe Seiyaku 92 Docetaxel hydrate (JAN) 1995 Rhone-Poulenc Rorer 93 Dofetilide 2000 Pfizer 94 Dolasetron mesylate (USAN) 1998 Hoechst Marion Roussel 95 Donepezil hydrochloride (JAN, USAN) 1997 Eisai 96 Dornase alfa 1994 Genentech 97 Dorzolamide hydrochloride (JAN, USAN) 1995 Merck 98 Dosmalfate 2000 Faes 99 Doxacurium chloride (INN, USAN) 1991 Wellcome 100 Doxercalciferol 1999 Bone Care Int. 101 Drospirenone 2000 Schering AG 102 Duteplase (INN, JAN) 1995 Sumitomo 103 Ebrotidine (INN) 1997 Ferrer 104 Ecabet sodium (JAN) 1993 Tanabe ; Boehringer Ing. 105 Efavirenz 1998 DuPont Pharm 106 Efonidipine hydrochloride (JAN) 1994 Zeria 107 Egualen sodium (JAN) 2000 Kotobuki Seiyaku 108 Emedastine difumarate (JAN)(USP) 1993 Kanebo ; Kowa 109 Entacapone 1998 Orion Pharma 110 Epalrestat 1992 Ono 111 Epinastine hydrochloride (JAN) 1994 Boehringer Ing.; Sankyo 112 Eprosartan mesylate (USAN) 1997 SmithKline Beecham 113 Eptilfibatide 1999 Cor Ther./Schering-Pl. 114 Erdosteine 1995 Pierre Fabre; Negma 115 Esomeprazole magnesium (USAN) 2000 Astra Zeneca 116 Exemestane 2000 Pharmacia 117 Factor VIII, recombinant 1992 Baxter 118 Factor VIIa 1996 NovoNordisk 119 Fadrozole hydrochloride hydrate (JAN) 1995 Ciba-Geigy 120 Famciclovir 1994 SmithKline Beecham 121 Faropenem sodium (JAN) 1997 Suntory 122 Fasudil hydrochloride (JAN) 1995 Asahi Chemical 123 Felbamate 1993 Carter-Wallace 124 Fenoldopam mesylate (USAN)(USP) 1998 Neurex 125 Fexofenadine hydrochloride (USAN) 1996 Hoechst Marion Roussel 126 Filgrastim, recombinant 1991 Amgen 127 Finasteride(USP) 1992 Merck 128 Fleroxacin 1992 Roche 129 Flosequinan 1992 Boots 130 Fludarabine phosphate (USAN) 1991 Berlex (Schering AG) 131 Flurithromycin ethylsuccinate (INNM) 1997 Pierrel 132 Flutrimazole 1995 Uriach 133 Fluvastatin sodium (USAN) 1994 Sandoz 134 Follitropin alfa 1996 Serono 135 Follitropin beta 1996 Organon 136 Fomepizole 1998 OrphanMedical/Cambridge 137 Fomivirsen sodium (USAN) 1998 Ciba Vision 138 Formestane 1993 Ciba-Geigy 139 Fosinopril sodium (USAN) 1991 Bristol-Myers Squibb 140 Fosphenytoin sodium (USAN) 1996 Warner-Lambert 141 Gabapentin 1993 Warner-Lambert 142 Gadoversetamide 2000 Mallinckrodt 143 Gallium nitrate 1991 Fujisawa 144 Ganirelix acetate (USAN) 2000 Organon 145 Gatifloxacin hydrate (JAN) 1999 Bristol-Myers Squibb 146 Gemcitabine hydrochloride (USAN) 1995 Lilly 147 Gemtuzumab ozogamicin (USAN) 2000 Celltech/Wyeth-Ayerst 148 Glatiramer acetate (USAN) 1997 Teva 149 Glimepiride 1995 Hoechst Marion Roussel 150 Glucagon, rDNA 1993 Novo-Nordisk 151 GMDP 1996 Peptech 152 Granisetron hydrochloride (USAN) 1991 Smith-Kline Beecham 153 Gusperimus hydrochloride (JAN) 1994 Nippon Kayaku 154 Halobetasol propionate (USAN) 1991 Bristol-Myers Squibb 155 Histrelin 1993 Roberts 156 Ibandronate sodium (USAN) 1996 Boehringer Mannheim 157 Ibutilide fumarate (USAN) 1996 Pharmacia & Upjohn 158 Iloprost 1992 Schering 159 Imidapril hydrochloride (JAN) 1993 Tanabe 160 Imiglucerase 1994 Genzyme 161 Imiquimod 1997 3M Pharmaceuticals 162 Incadronate disodium (JAN) 1997 Yamanouchi 163 Indinavir sulfate (USAN) 1996 Merck 164 Insulin lispro 1996 Lilly 165 Interferon Alfacon-1 1997 Amgen 166 Interferon, β-1a 1996 Biogen 167 Interferon, β-１b 1993 Berlex 168 Interferonγ-1a , recombinant 1992 Maruho 169 Interferonγ-1b, recombinant 1991 Genentech 170 Ioflupane 2000 Nycomed Amersham 171 Irbesartan 1997 Sanofi 172 Irinotecan hydrochloride (JAN,USAN) 1994 Yakult Honsha ; Daiichi 173 Itopride hydrochloride (JAN) 1995 Hokuriku 174 Kinetin 1999 Osmotics Corp. 175 Lacidipine 1991 Glaxo; Guidotti ; Zambon 176 Lafutidine (JAN) 2000 UCB ; Taiho 177 Lamivudine 1995 Glaxo Wellcome 178 Lanoconazole 1994 Nihon Nohyaku; Tsumura 179 Lanreotide acetate (USAN) 1995 Beaufour-Ipsen 180 Lansoprazole 1992 Laboratoires Takeda 181 Latanoprost 1996 Pharmacia & Upjohn 182 Leflunomide 1998 Hoechst Marion Roussel 183 Lepirudin 1997 Hoechst Marion Roussel 184 Lercanidipine (INN) 1997 Byk Gulden 185 Letrozole(USP) 1996 Novartis 186 Levalbuterol hydrochloride (USAN) 1999 Sepracor 187 Levetiracetam 2000 UCB 188 Levobupivacaine hydrochloride (USAN) 2000 Purdue Pharma 189 Levocabastine hydrochloride (USAN) 1991 Janssen (J & J) 190 Levofloxacin (JAN, USAN) 1993 Daiichi 191 Levosimendan 2000 Orion 192 Linezolid 2000 Pharmacia Corp 193 Liranaftate 2000 Tosoh 194 Lodoxamide tromethamine (USAN) 1992 Alcon 195 Lomerizine hydrochloride (JAN) 1999 Kanebo 196 Lopinavir 2000 Abbott; Triangle Pharm. 197 Loracarbef (USAN)(USP) 1992 Lilly 198 Lornoxicam 1997 Nycomed Amersham 199 Losartan potassium (JAN, USAN) 1994 DuPont Merck; Merck 200 Loteprednol etabonate (USAN) 1998 Bausch & Lomb 201 Lyme disease vaccine 1999 SmithKline Beecham 202 Masoprocol 1992 Block Drug 203 Maxacalcitol (JAN, USAN) 2000 Chugai 204 Meloxicam 1996 Boehringer Ingelheim 205 Meropenem trihydrate (JAN)(USP) 1994 Zeneca 206 Mibefradil dihydrochoride (USAN) 1997 Roche 207 Miglitol 1998 Sanofi 208 Milnacipran hydrochloride (JAN) 1997 Pierre Fabre 209 Miltefosine 1993 Asta Medica 210 Mirtazapine 1994 Organon 211 Mivacurium chloride (USAN) 1992 Wellcome 212 Mivotilate 1999 Yuhan Corp 213 Mizolastine 1998 Galderma 214 Modafinil 1994 Lafon 215 Moexipril hydrochloride (USAN) 1995 Schwarz 216 Mofezolac 1994 Taiho 217 Montelukast sodium (USAN) 1998 Merck 218 Mosapramine hydrochloride (JAN) 1991 Yoshitomi 219 Mosapride citrate (JAN) 1998 Dainippon 220 Moxifloxacin hydrochloride (USAN) 1999 Bayer 221 Moxonidine 1991 Beiersdorf; Giulini (Solvay) 222 Mycophenolate mofetil (USAN) 1995 Roche 223 Nadifloxacin 1993 Otsuka 224 Naftopidil 1999 Kanebo; Asahi 225 Nalmefene hydrochloride 1995 Ohmeda 226 Naratriptan hydrochloride (USAN) 1997 Glaxo Wellcome 227 Nartograstim (JAN) 1994 Kyowa Hakko 228 Nateglinide 1999 Ajinomoto ; Yamanouchi 229 Nebivolol (INN, USAN) 1997 Menarini 230 Nedaplatin 1995 Shionogi 231 Nefazodone hydrochloride (USAN) 1994 Bristol-Myers Squibb 232 Nelfinavir mesylate (USAN) 1997 Agouron 233 Neltenexine 1993 Pulitzer ; IBI , etc 234 Nemonapride 1991 Yamanouchi 235 Neticonazole hydrochloride (JAN) 1993 SS Pharmaceutical 236 Nevirapine 1996 Boehringer Ingelheim 237 Nifekalant hydrochloride (JAN) 1999 Mitsui 238 Olanzapine 1996 Lilly 239 Olopatadine hydrochloride (USAN) 1997 Alcon 240 Olprinone hydrochloride (JAN) 1996 Eisai 241 Orlistat 1998 Roche 242 Oseltamivir phosphate (USAN) 1999 Roche 243 Oxaliplatin 1996 Sanofi 244 Paclitaxel 1993 Bristol-Myers Squib 245 Panipenem/betamipron 1994 Sankyo 246 Pantoprazole sodium (USAN) 1994 Byk Gulden ; Schwarz Pharm 247 Paricalcitol 1998 Abbott 248 Parnaparin sodium (INN, JAN) 1993 Alfa Wassermann 249 Paroxetine hydrochloride hydrate(JAN) 1991 Smith-Kline Beecham 250 Pegaspargase 1994 Rhone-Poulenc Rorer 251 Pemirolast potassium (JAN, USAN) 1991 Bristol-Myers Squibb 252 Penciclovir 1996 SmithKline Beecham 253 Pentostatin 1992 Warner-Lambert 254 Pidotimod 1993 Poli ; Boehringer Mannh. 255 Pilsicainide hydrochloride (JAN) 1991 Suntory; Daiichi 256 Pimobendan 1994 Boehringer Ingelheim 257 Pioglitazone hydrochloride (JAN, USAN) 1999 Lilly 258 Pirmenol hydrochloride (JAN, USAN) 1994 Warner-Lambert 259 Pivagabine 1997 Angelini 260 Polaprezinc 1994 Zeria 261 Porfimer sodium (JAN, USAN) 1993 Quadra Logic; Cyanamid 262 Pramipexole dihydrochloride (USAN) 1997 Pharmacia & Upjohn 263 Pramiracetam sulfate (USAN) 1993 Lusofarmaco ; Firma etc 264 Pranlukast hydrate (JAN) 1995 Ono 265 Prezatide copper acetate (USAN) 1996 ProCyte 266 Propagermanium 1994 Sanwa Kagaku; Yamanouchi 267 Propiverine hydrochloride (JAN) 1992 Apogepha 268 Pumactant (BAN) 1994 Britannia 269 Quetiapine fumarate (USAN) 1997 Zeneca 270 Quinagolide hydrochloride (BAN) 1994 Sandoz 271 Rabeprazole sodium (USAN, JAN) 1998 Eisai 272 Racecadotril (INN) (Acetorphan) 1993 Bioprojet 273 Raloxifene hydrochloride (USAN) 1998 Lilly 274 Raltitrexed 1996 Zeneca 275 Ramatroban (INN, JAN) 2000 Bayer 276 Ramosetron hydrochloride (JAN) 1996 Yamanouchi 277 Ranitidine bismuth citrate (USAN) 1995 Glaxo Wellcome 278 Rapacuronium bromide 1999 Akzo Nobel 279 Reboxetine mesylate (USAN) 1997 Pharmacia & Upjohn 280 Remifentanil hydrochloride (USAN) 1996 Glaxo Wellcome 281 Repaglinide 1998 NovoNordisk; Schering Pl. 282 Reteplase 1996 Boehringer Mannheim 283 Reviparin sodium (INN, JAN) 1993 Knoll 284 Rifabutin(USP) 1992 Farmitalia Carlo Erba 285 Riluzole (USAN, JAN) 1996 Rhone-Poulenc Rorer 286 Rimexolone(USP) 1995 Alcon 287 Risedronate sodium (USAN) 1998 Procter Gamble & HMR 288 Risperidone 1993 Janssen ; Organon 289 Ritonavir 1996 Abbott 290 Rivastigmine tartrate 1997 Novartis 291 Rizatriptan benzote (USAN) 1998 Merck 292 Rocuronium bromide (USAN, INN) 1994 Organon 293 Rofecoxib 1999 Merck 294 Romurtide (INN, JAN) 1991 Daiichi 295 Ropinirole hydrochloride (USAN) 1996 SmithKline Beecham 296 Ropivacaine (INN, JAN) 1996 Astra 297 Rosiglitazone maleate (USAN) 1999 SmithKline Beecham 298 Rufloxacin hydrochloride (INNM) 1992 Mediolanum; ISF (SKB) 299 Sapropterin hydrochloride (JAN) 1992 Maruho 300 Saquinavir mesylate (USAN) 1995 Roche 301 Sargramostim, recombinant(USP) 1991 Immunex ; Hoechst-Rous. 302 Sarpogrelate hydrochloride (JAN) 1993 Tokyo Tanabe 303 Seratrodast 1995 Takeda 304 Sertaconazole nitrate 1992 Ferrer ; Lab. Robert 305 Sertindole 1996 Lundbeck 306 Sibutramine hydrochloride (USAN) 1998 Knoll 307 Sildenafil citrate (USAN) 1998 Pfizer 308 SKI-2053R 1999 SK Pharma 309 Sobuzoxane 1994 Zenyaku Kogyo 310 Somatomedin-1 1994 Pharmacia 311 Somatotropin 1994 Genentech 312 Sorivudine 1993 Yamasa Shoyu; Nippon Sh. 313 Sparfloxacin 1993 Dainippon 314 Spirapril hydrochloride (USAN) 1995 Sandoz 315 Stavudine 1994 Bristol-Myers Squibb 316 Succimer 1991 McNeil Consumer Prod. 317 Sumatriptan succinate (USAN) 1991 Glaxo 318 Suplatast tosilate (JAN) 1995 Taiho 319 Tacalcitol 1993 Teijin ; Fujisawa 320 Tacrine hydrochloride (USAN) 1993 Warner-Lambert 321 Tacrolimus hydrate (JAN) 1993 Fujisawa 322 Talipexole hydrochloride (JAN) 1996 Boehringer Ingelheim 323 Taltirelin hydrate (JAN) 2000 Tanabe 324 Tamsulosin hydrochloride (JAN, USAN) 1993 Yamanouchi 325 Tandospirone citrate (JAN, USAN) 1996 Sumitomo 326 Tasonermin (INN) 1999 Boehringer Ingelheim 327 Tazarotene (USAN) 1997 Allergan 328 Tazobactam sodium (USAN, JAN) 1992 Lederle (Am. cyanamid) 329 Telmesteine 1992 Pulitizer; SPA 330 Telmisartan 1999 Boehringer Ingelheim 331 Temafloxacin hydrochloride (USAN) 1991 Abbott; ICI 332 Temocapril hydrochloride (JAN, USAN) 1994 Sankyo; Boehringer Ing. 333 Temozolomide 1999 Schering-Plough 334 Terbinafine hydrochloride (JAN) 1991 Sandoz 335 Tiagabine hydrochloride (USAN) 1996 NovoNordisk 336 Tilisolol hydrochloride (JAN) 1992 Maruho ; Toyama 337 Tiludronate disodium (USAN) 1995 Sanofi 338 Tirilazad mesylate (USAN) 1995 Pharmacia & Upjohn 339 Tirofiban hydrochloride (USAN) 1998 Merck 340 Tolcapone 1997 Roche 341 Topiramate 1995 Johnson & Johnson 342 Topotecan hydrochloride (USAN) 1996 SmithKline Beecham 343 Torasemide (JAN, INN) (torsemide (USAN)) 1993 Boehringer Mannheim 344 Trandolapril 1993 Roussel Uclaf; Knoll 345 Tretinoin tocoferil (INN, JAN) 1993 Nisshin Flour Milling 346 Trimetrexate glucuronate (USAN) 1994 US Bioscience 347 Troglitazone (JAN, USAN) 1997 Sankyo 348 Tropisetron hydrochloride (INN) 1992 Sandoz 349 Trovafloxacin mesylate (USAN) 1998 Pfizer 350 Unoprostone isopropyl ester (JAN) 1994 Fujisawa 351 Valaciclovir hydrochloride (INN, JAN) 1995 Glaxo Wellcome 352 Valrubicin 1999 Medeva 353 Valsartan 1996 Novartis 354 Venlafaxine hydrochloride (USAN) 1994 Wyeth-Ayerst 355 Verteporfin 2000 QLT ; Ciba Vision 356 Voglibose 1994 Takeda 357 Zafirlukast 1996 Zeneca 358 Zalcitabine (USP) 1992 Roche 359 Zaleplon 1999 American Home Products 360 Zaltoprofen 1993 Nippon Chemiphar ; Zeria 361 Zanamivir (USAN) 1999 Glaxo Wellcome 362 Zileuton 1997 Abbott 363 Zinostatin stimalamer (JAN, INN) 1994 Yamanouchi ; Kuraray 364 Ziprasidone hydrochloride (USAN) 2000 Pfizer 365 Zofenopril calcium (USAN) 2000 Menarini 366 Zoledronate disodium (USAN) 2000 Novartis 367 Zolmitriptan 1997 Zeneca

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